Table 3.

Caregivers: multivariable linear regression of association of initial stroke severity on deviation from population norm values of health-related quality of life (caregiver ${\mathrm{\Delta }}_U$)

	Model 1		Model 2		Model 3 (main model)		Model 4 (sensitivity analysis)
	${\mathrm{\Delta }}_{U_{\text{3m}}}$	${\mathrm{\Delta }}_{U_{\text{12m}}}$	${\mathrm{\Delta }}_{U_{\text{3m}}}$	${\mathrm{\Delta }}_{U_{\text{12m}}}$	${\mathrm{\Delta }}_{U_{\text{3m}}}$	${\mathrm{\Delta }}_{U_{\text{12m}}}$	${\mathrm{\Delta }}_{U_{\text{3m}}}$	${\mathrm{\Delta }}_{U_{\text{12m}}}$
	Coefficient (SE)	Coefficient (SE)	Coefficient (SE)	Coefficient (SE)	Coefficient (SE)	Coefficient (SE)	Coefficient (SE)	Coefficient (SE)
n	297	297	297	297	270	268	194	210
Initial stroke severity, NIHSSa	− 0.006* (0.003)	− 0.004 (0.002)	− 0.007** (0.003)	− 0.004 (0.002)	− 0.001 (0.003)	− 0.003 (0.003)	0.002 (0.003)	0.001 (0.002)
Caregiver age, years			− 0.002* (0.001)	0.000 (0.001)	− 0.002 (0.001)	0.000 (0.001)	− 0.000 (0.001)	0.002 (0.001)
Caregiver female sex			− 0.043 (0.026)	− 0.029 (0.030)	− 0.058* (0.028)	− 0.038 (0.029)	− 0.017 (0.023)	− 0.021 (0.027)
Caregiver relationship
Spouse/partner					Ref.	Ref.	Ref.	Ref.
Adult child					0.013 (0.037)	0.024 (0.034)	0.007 (0.029)	0.003 (0.031)
Other					− 0.023 (0.056)	− 0.020 (0.051)	0.027 (0.046)	− 0.009 (0.048)
Discharge diagnosis
Transient ischaemic attack					Ref.	Ref.	Ref.	Ref.
Ischaemic stroke					0.006 (0.033)	0.053 (0.030)	− 0.028 (0.026)	0.058* (0.027)
Intracerebral haemorrhage					− 0.060 (0.056)	0.119* (0.051)	− 0.077 (0.045)	0.126** (0.047)
Discharge destination
Home or rehabilitation					Ref.	Ref.	Ref.	Ref.
Nursing home					− 0.028 (0.046)	0.035 (0.020)	− 0.006 (0.039)	− 0.034 (0.047)
Other					− 0.024 (0.033)	0.020 (0.064)	0.030 (0.055)	− 0.044 (0.054)
Survivor health state valueb					0.117* (0.047)	0.253*** (0.046)	0.164* (0.063)	0.119 (0.065)
Survivor mRSb							− 0.001 (0.016)	− 0.001 (0.015)
Caregiver anxiety scoreb							− 0.011* (0.004)	− 0.000 (0.004)
Caregiver depression scoreb							− 0.026*** (0.005)	− 0.037*** (0.005)
Survivor anxiety scoreb							0.003 (0.004)	0.003 (0.004)
Survivor depression scoreb							0.011** (0.004)	− 0.004 (0.005)
R2	0.022	0.009	0.042	0.013	0.091	0.141	0.398	0.416
Adjusted-R2	0.019	0.006	0.032	0.003	0.056	0.107	0.347	0.370
df	295	295	293	293	259	257	178	194
AIC	− 58.550	− 22.477	− 60.710	− 19.700	− 50.553	− 86.393	− 176.135	− 164.542

Ref. reference category, NIHSS National Institutes of Health Stroke Scale, mRS modified Rankin Scale, df residual degrees of freedom, AIC Akaike information criterion

*p < 0.05; **p < 0.01; ***p ≤ 0.001

^aNIHSS score at admission, survivors with transient ischaemic attack assigned NIHSS = 0

^bVariable collected at same time point as ${\mathrm{\Delta }}_U$