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. 2020 Oct 15;10:17500. doi: 10.1038/s41598-020-74435-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The relationship between annual peak timing and amplitude estimates for Shiga Toxin-producing E. coli (STEC) in the US in 1996 to 2017. The multi-panel plot consists of two panels depicting forest plots for peak timing (upper panel) and amplitude (left panel) estimates along with their 95% confidence intervals by year, and the main panel demonstrating the associations between these two seasonality characteristics. Dashed red lines indicate the average peak timing and average amplitude across all years. The colour shade indicates the year of reporting and helps to note the decline in amplitude and the overall tendency to early peak timing that explain the nature of the observed positive correlation and potential synchronization over time.