Table 2.
Summary of lncRNA implicated in regulation of MDSC development and function.
| LncRNA | Disease | Function | References |
|---|---|---|---|
| Hox antisense intergenic RNA (HOTAIR) | Hepatocellular carcinoma | Overexpression of HOTAIR recruits TAMs/MDSCs through the release of CCL2 | (126, 127) |
| Hox antisense intergenic RNA (HOTAIR) | Head and neck squamous cell carcinoma | HOTAIR functions as a factor in HPV16 increasing MDSC recruitment in head and neck squamous cell carcinoma | (128) |
| Retinal non-coding RNA3(RNCR3) | B16 tumor-bearing mice | RNCR3 stimulates differentiation and activity of MDSC through miR-185-5p/Chop | (129) |
| Plasmacytoma variant translocation 1 (Pvt1) | C57BL/6 tumor-bearing mice | Pvt1 augments the expression of Arg1 and ROS in G-MDSCs and decreases T-cell mediated antitumor reactions | (130) |
| Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) | Lung cancer | MALAT1 negatively controls MDSCs and functions as a regulator of MDSCs differentiation | (131) |
| RUNX1 overlapping RNA (RUNXOR) | Lung cancer | RUNXOR moderates MDSCs immunosuppression by regulating RUNX1 | (132) |
| CCAAT/enhancer binding protein β (C/EBPβ) | C57BL/6 tumor-bearing mice | Lnc-C/EBPβ controls immune suppressive function and differentiation of MDSCs | (132) |
| CCAAT/enhancer binding protein β (C/EBPβ) | C57BL/6 tumor-bearing mice | Lnc-C/EBPβ moderates differentiation of MDSCs through downregulation of IL4i1 | (133) |
| AK036396 | Lung cancer | AK036396 stops maturation and accelerates immunosuppression of PMN-MDSCs by increasing the ficolin B stability | (134) |
HOTAIR, HOX transcript antisense RNA; TAM, Tumor-associated macrophages; RNCR3, Retinal non-coding RNA 3; Pvt1, Plasmacytoma variant translocation 1; MALAT1, Metastasis-associated lung adenocarcinoma transcript 1; RUNXOR, RUNX1 overlapping RNA; C/EBPβ, CCAAT/enhancer binding protein β.