Table 2. Univariate and multivariate analysis to identify prognostic factors in younger patients.
| Variable | Disease-free survival | Overall survival | ||||||||||
| Univariate | Multivariate | Univariate | Multivariate | |||||||||
| p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | |||||
| Age ≤40 years | 0.046 | 1.116 (1.003-1.358) | 0.277 | 1.091 (0.931-1.278) | 0.016 | 1.219 (1.038-1.432) | 0.035 | 1.199 (1.013-1.418) | ||||
| Male sex | 0.192 | 1.140 (0.936-1.388) | 0.039 | 1.256 (1.011-1.560) | 0.001 | 1.162 (0.553-1.808) | ||||||
| Vascular invasion | <0.001 | 2.277 (1.957-2.659) | 0.781 | 0.956 (0.694-1.315) | 0.039 | 0.796 (0.641-0.989) | 0.045 | 1.424 (1.008-2.012) | ||||
| Tumor number >3 | 0.015 | 1.371 (1.063-1.768) | 0.141 | 0.815 (0.621-1.070) | <0.001 | 2.138 (1.696-2.694) | 0.030 | 1.325 (1.028-1.709) | ||||
| Tumor diameter >5 cm | <0.001 | 1.562 (1.363-1.790) | 0.024 | 1.188 (1.023-1.381) | <0.001 | 2.283 (1.958-2.662) | 0.000 | 1.547 (1.304-1.836) | ||||
| HBsAg-positive Hepatitis C antibody positivity |
0.026 0.390 |
1.259 (1.028-1.542) 1.005 (0.995-1.010) |
0.103 | 1.187 (0.966-1.459) | 0.064 0.240 |
1.220 (0.988-1.506) 1.007 (0.994-1.012) |
||||||
| Platelet as ×109/L | 0.097 | 0.999 (0.999-1.000) | 0.037 | 0.999 (0.998-1.000) | 0.447 | 1.000 (0.999-1.001) | ||||||
| Albumin in g/L | 0.001 | 0.975 (0.962-0.989) | 0.785 | 0.998 (0.981-1.015) | <0.001 | 0.949 (0.936-0.963) | 0.089 | 0.984 (0.966-1.002) | ||||
| Prealbumin in mg/L | <0.001 | 0.997 (0.996-0.998) | 0.008 | 0.998 (0.997-1.000) |
<0.001 | 0.995 (0.994-0.996) | 0.000 | 0.997 (0.995-0.995) | ||||
| ALT in U/L | 0.121 | 1.001 (1.000-1.003) | 0.008 | 1.002 (1.001-1.003) | 0.436 | 0.999 (0.997-1.001) | ||||||
| AST in U/L | <0.001 | 1.003 (1.002-1.005) | 0.098 | 1.001 (1.000-1.003) | <0.001 | 1.005 (1.004-1.006) | 0.001 | 1.003 (1.001-1.005) | ||||
| AFP ≥400 ng/mL | <0.001 | 1.291 (1.132-1.471) | 0.130 | 1.111 (0.970-1.273) | <0.001 | 1.471 (1.280-1.691) | 0.025 | 1.183 (1.022-1.369) | ||||
| Incomplete tumor capsule | <0.001 | 1.551 (1.357-1.772) | 0.002 | 1.255 (1.087-1.448) | <0.001 | 1.872 (1.629-2.153) | 0.000 | 1.364 (1.172-1.586) | ||||
| Anatomical hepatectomy | <0.001 | 1.678 (1.461-1.927) | 0.009 | 1.228 (1.053-1.432) | <0.001 | 1.892 (1.635-2.190) | 0.360 | 1.081 (0.915-1.276) | ||||
| Portal hypertension | 0.005 | 1.237 (1.067-1.434) | 0.037 | 1.174 (1.010-1.364) | 0.001 | 1.310 (1.120-1.531) | 0.052 | 1.182 (0.998-1.400) | ||||
| BCLC stage B/C | <0.001 | 1.591 (1.473-1.719) | <0.001 | 1.436 (1.212-1.700) | <0.001 | 1.976 (1.824-2.140) | 0.002 | 1.345 (1.115-1.621) | ||||
Abbreviations: AFP, alpha-fetoprotein; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BCLC, Barcelona Clinic Liver Cancer; CI, confidence interval; OR, odds ratio.