REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
IL-17RA	Lifespan Bioscience	Cat#LS-C359381
IL-17RC	Lifespan Bioscience	Cat#LS-400522
FOSL	Boster	Cat# A03927
IL-36G	Santa Cruz Biotechnology	Cat#Sc-80056; RRID: AB_2124893
TNFAIP3	Abcam	Cat#Ab74037; RRID: AB_1524499
APOBEC3A	Lifespan Bioscience	Cat#LS-C98892-400
Biological Samples
Skin Biopsies	UCLA	N/A
Skin Biopsies	University of Michigan	N/A
PBMCs	MGH	N/A
Chemicals, Peptides, and Recombinant Proteins
Maxima H-RT and Buffer	ThermoFisher Scientific	Cat#EP0751
dNTPs	New England Biolabs	Cat#N0447L
Polyethylene Glycol 8000	Fisher Scientific	Cat#BP233-1
SUPERase∗In RNase inhibitor	ThermoFisher Scientific	Cat#AM2696
Exonuclease I and Buffer	New England Biolabs	Cat#M0293S
1M Tris-HCl, pH 8.0	ThermoFisher Scientific	Cat#15568025
Klenow Fragment (3’®5’ exo-)	New England Biolabs	Cat#M0212L
KAPA 2x HiFi HotStart PCR mix	Kapa Biosystems	Cat#KK2602
Nextera XT Kit	Illumina, Inc	Cat#FC-131-1096
UltraPure DNase/Rnase-Free Distilled Water	ThermoFisher Scientific	Cat#10977015
TWEEN 20	Fisher Scientific	Cat#BP337-100
Sodium Dodecyl Sulfate (SDS) Solution	Sigma	Cat#71736-100mL
TE Buffer	ThermoFisher Scientific	Cat#12090015
Critical Commercial Assays
mRNA Capture Beads	Chemgenes Corp.	Cat#MACOSKO-2011-10B
KAPA 2x HiFi HotStart PCR mix	Kapa Biosystems	Cat#KK2602
NextSeq500 (75 cycles)	Illumina	Cat#20024906
Nova-Seq S2 (100 cycles)	Illumina	Cat#20028316
Deposited Data
Raw and Processed data	GEO	GEO: GSE150672
Experimental Models: Cell Lines
HEK293	ATCC	CRL-1573
NIH/3T3s	ATCC	CRL-1658
Oligonucleotides
Template-Switching Oligo: AAGCAGTGGTATCAACGCAG AG TGAATrGrGrG	This Paper	N/A
SMART PCR Primer: AAGCAGTGGTATCAACGCAGAGT	This Paper	N/A
S3 Randomer:AAGCAGTGGTAT CAACGCAGAGTGANNNGGNNNB	This Paper	N/A
P5-SMART Hybrid Oligo: AATGATACGGCGACCACCG AGATCTACACGCCTGTCCGC G-GAAGCAG TGGTA TCAACGCAGAGT∗A∗C	This Paper	N/A
Custom Read 1 Primer: GCCTGTCCGCGGAAGC AGTGGTATCAACGCAGAGTAC	This Paper	N/A
Software and Algorithms
Seurat	Satija et al. 2015	http://satijalab.org/seurat/
SCANPY	Wolf et al. 2018	http://github.com/theislab/Scanpy