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. 2020 Oct 15;10:17448. doi: 10.1038/s41598-020-74491-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Duodenal acid perfusion relaxes the proximal stomach. IGP during saline perfusion (black dots) and acid perfusion (white dots) was evaluated using a high-resolution manometry catheter. (A) Time curve of IGP during saline or acid perfusion. (B) AUC of IGP during saline or acid perfusion. n = 9 for saline perfusion and n = 10 for acid perfusion. Data are mean ± SEM; **P < 0.01. AUC, area under the curve; IGP, intragastric pressure.