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. 2020 Oct 15;10:17448. doi: 10.1038/s41598-020-74491-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Acid-induced impairment of the duodenal mucosal barrier is not mediated by mast cells. Mucosal barrier function after acid perfusion following treatment with placebo (black dots) and DSCG (white dots) was evaluated in Ussing chambers by measuring TEER (A) and passage of FITC-dx4 (B). n = 10 for both groups. (C) Acid-induced reduction in TEER in wild type and in deficient mast cell Cpa3Cre/⁺ mice. Results are expressed relative to the mean of the control group. DSCG, disodiumcromoglycate; FITC-dx4, fluorescently labeled dextran of 4 kDa; TEER, transepithelial electrical resistance; WT, wild type.