Table 1.
Preventive strategies for chemotherapy-induced alopecia (CIA) in animal models and in human trials
| Studied in animal models | Studied in human trials: not effective | Studied in human trials: effective |
|---|---|---|
| Anti-doxorubicin29 | Topical minoxidil23 | AS101a30 |
| Topical epinephrine and norepinephrine31 | Parathyroid hormone receptor (PPR) ligands32 | Scalp cooling9, 33, 34 |
| Topical n-acetyl cysteine35 | Scalp tourniquet36 | |
| Topical antioxidants (resveratrol, aminothiol)31 | Topical calcitriol37 | |
| Topical cyclosporine A38 | DHL-HisZnNA39 | |
| Immunomodulators (Il-1,40 imuvert41) | ||
| Acid FGF, EGF40 | ||
| CDK2 inhibitors42 | ||
| Caspase-3 inhibitors43 | ||
| Multi-target iron chelator M3044 |
a
More evidence needed.