Table 1.
Necroptosis-inducing agents and their therapeutic applications.
| Necroptosis-inducing agent | Type of cells | Dosage | Ref. |
|---|---|---|---|
| Inorganic salts and metal complexes | |||
| CoCl2 31 (Cobalt chloride) |
HT-29 (human colon carcinoma cells) | 300 μmol/L | 104 |
| LiCl 32 (Lithium chloride) 
|
Human primary Schwannoma cells | 20 mmol/L | 105 |
33 (Cisplatin)
|
L929 cells (mouse fibroblast cells) | 100 μmol/L | 106 |
|
34 (Rhenium(V) oxo complexes) Natural products 
|
A549 cells (human lung cancer cells) | 20 μmol/L | 107 |
35 (Matrine)
|
Mz-ChA-1 and QBC939 (human cholangiocarcinoma cells) | 1.5 mg/mL | 108 |
36 (Neoalbaconol)
|
C666-1 and HK1 cells (human nasopharyngeal carcinoma cells) | 40 μmol/L | 109 |
37 (Shikonin)
|
C6 and U87 (human glioma cells) | 3 μmol/L | 95 |
38 (Emodin)
|
U251 (human glioblastoma cells) | 20 μmol/L | 110 |
|
39 (Ungeremine) Antitumor agents 
|
CCRF-CEM (human leukemia cells) | 4.89 μmol/L | 111 |
40 (Etoposide)
|
MDA-MB-231 (human breast cancer cells) HT1080 (human sarcoma cells) |
20 mmol/L | 112 |
41 (Givinostat)
|
HDLM-2 and L-540 HL cells (human Hodgkin lymphoma cells) | 100 μmol/L 5 μmol/L |
113 |
42 (Sorafenib)
|
MDA-MB-435 cells (human breast cancer cells) | 40 μmol/L | 114 |
43 (3-Bromopyruvate)
|
TE671 and RMS13 cells (human bone marrow transverse muscle carcinoma cells) | 200 nmol/L | 115 |
44 (Obatoclax)
|
CRC cells (human colorectal cancer cells) | 50 μg/mL | 116 |
45 (5-Fluorouracil)
|
|||
46 (IDN-7314)
|
A549 cells (human lung cancer cells) | 100 μmol/L | 117 |
47 (Methyl methanesulfonate)
|
MiaPaCa-2 (human pancreatic cells) | 15 μmol/L | 118 |
48 (ZZW-115)
|
NCI–H28 cells (human malignant pleural mesothelioma cells) | 100 μmol/L | 119 |
49 (Diarachidonoylphosphoethanolamine)
|
A375 Cells (human melanoma cells) | 8 μmol/L | 120 |
50 (3u)
|
SKOV3 (human ovarian cells) | 12.5 μmol/L | 121 |
|
51 (673 A) Non-antitumor agents 
|
U251MG, U87MG cells (human glioblastoma cells) | 15 μmol/L | 122 |
52 (FTY720)
|
MDA-MB-231 (human breast cancer cells) | 40 μmol/L | 123 |
53 (Miconazole)
|
Hep3B (human hepatoma cells) | 50 μmol/L | 124 |
|
54 (Fenofibrate) Other necroptosis inducers  17 (Z-VAD-fmk) |
Classically activated macrophages | 20 μmol/L | 125 |
55 (Furosine)
|
Primary hepatocytes | 100 μg/mL | 126 |
56 (LGH00168)
|
A549 cells (human lung cancer cells) | 3.26 μmol/L | 127 |
57 (24(S)-hydroxycholesterol)
|
SH-SY5Y cells (human neuroblastoma cells) | 50 μmol/L | 128 |
| 58 (Bisphenol A) | SH-SY5Y (human neuroblastoma cells) | 1 nmol/L | 129 |