Promising strategies to improve the efficacy of PDT for PCAR. Promising results from the application of PDT for PCAR have been achieved using innovative photoimmunoconjugates and photosensitizer-loaded nanocarriers, which can in principle be combined to develop targeted photonanomedicines. Regarding the integration into the clinical practice, PDT may synergize with clinical chemotherapies, and innovative lighting solutions (e.g., implantable light panels and diffusing tip laser wands) may aid in improving the efficacy of PDT for PCAR. To overcome the difficulty of reaching occult PCAR with light, radiotherapy-activated PDT may be a promising solution.