Figure 2.

Overlap of differentially expressed genes for L-HES and SS. Shared and unique gene expression in SS and L-HES are shown with relationships to their respective roles in disease, which may lead to diagnostic improvements. Red circle: Differential gene expression in SS CD3⁺CD4⁺CD45RO⁺ T cells compared to normal CD3⁺CD4⁺CD45RO⁺ T cells [22]. Blue circle: Differential gene expression in L-HES CD3⁻CD4⁺ T cells compared to normal CD3⁺CD4⁺ T cells [30]. Center overlap: Gene expression abnormalities shared by SS and L-HES may reflect benign or pre-neoplastic proliferative and inflammatory phenotypes. Excluded areas to the right and left represent abnormal gene expression unique to SS or L-HES, respectively. SS-unique genes have been associated with a number of cancer-promoting phenotypes.