Figure 3.

Heat map based on NB-hop gene expression in the batch-adjusted test set. The expression values for each gene belonging to the NB-hop signature (rows) have been scaled and are represented by pseudo-colors in the heat map. Red color corresponds to high level of expression and blue color corresponds to low level of expression. Patients (columns) are divided into two groups according to NB-hop predictions. Indicated on top of the heat map are age groups, INSS stage, MYCN status, event overall, event-free and NB-hop prediction with the relative color legend. The expression value of the seven NB-hop genes was grouped by hierarchical clustering. The hierarchical clustering dendogram is shown on the left. F: Favorable. UF: Unfavorable. NB-hop: neuroblastoma hypoxia outcome predictor.