Table 2.
NB-hop gene signature used in the prognostic model.
| NB-hop | Gene Title | Affymetrix Probe Sets | Chromosome | Band | Hazard Ratio (95% CI) | p Value |
|---|---|---|---|---|---|---|
| High Expression is Associated with Poor Prognosis | ||||||
| PGK1 | phosphoglycerate kinase 1 | 200738_s_at, 17356_s_at | X | q21.1 | 6.5 (3.9–10.7) | <0.0001 |
| PDK1 | pyruvate dehydrogenase kinase, isozyme 1 | 206686_at, 226452_at | 2 | q31.1 | 1.8 (1.4–2.4) | <0.0001 |
| MTFP1 | mitochondrial fission process 1 | 223172_s_at | 22 | q12.2 | 2.4 (1.8–3.1) | <0.0001 |
| FAM162A | family with sequence similarity 162, member A | 223193_x_at | 3 | q21.1 | 1.9 (1.3–2.8) | <0.0001 |
| EGLN1 | egl nine homolog 1 (C. elegans) | 224314_s_at | 1 | q42.2 | 1.0 (0.5–2.0) | >0.05 |
| AK4 | adenylate kinase 4 | 230630_at | 1 | p31.3 | 1.1 (0.7–1.6) | >0.05 |
| High Expression is Associated with Good Prognosis | ||||||
| ALDOC | aldolase C, fructose-bisphosphate | 202022_at | 17 | q11.2 | 0.7 (0.5, 0.8) | <0.001 |
Univariate analysis was carried out by Cox regression using overall survival in the batch-adjusted training set. Significant p-values are depicted in bold. Genes with a hazard ratio greater than 1 were associated with poor prognosis. Genes with a hazard ratio smaller than 1 were associated with good prognosis. CI: confidence interval; NB: neuroblastoma.