Table 3.
Univariate and multivariate analysis of overall and event-free survival in the batch-adjusted test set.
| Univariate Analysis | Multivariate Analysis | |||||
|---|---|---|---|---|---|---|
| Covariate | HR | 95% CI | p Value | HR | 95% CI | p Value |
| Overall survival | ||||||
| NB-hop (UF vs. F) | 5.4 | (3.9–7.4) | <2.0 × 10−16 | 1.8 | (1.2–2.6) | 4.20 × 10−3 |
| Age at diagnosis (≥18 months vs. <18 months) | 7.4 | (5.0–10.9) | <2.0 × 10−16 | 3.6 | (2.3–5.5) | 8.50 × 10−9 |
| INSS stage (4 vs. 1, 2, 3, 4 s) | 5.9 | (4.0–8.5) | <2.0 × 10−16 | 2 | (1.3–3.1) | 8.60 × 10−4 |
| MYCN status (Amplified vs. normal) | 6.8 | (5.0–9.4) | <2.0 × 10−16 | 2.7 | (1.8–3.9) | 3.70 × 10−7 |
| Event-free survival | ||||||
| NB-hop (UF vs. F) | 3.4 | (2.6–4.5) | <2.0 × 10−16 | 1.7 | (1.2–2.5) | 1.40 × 10−3 |
| Age at diagnosis (≥18 months vs. <18 months) | 3 | (2.2–3.9) | 7.11 × 10−15 | 1.8 | (1.3–2.5) | 2.20 × 10−4 |
| INSS stage (4 vs. 1, 2, 3, 4 s) | 2.9 | (2.2–3.8) | 2.83 × 10−14 | 1.6 | (1.1–2.2) | 4.60 × 10−3 |
| MYCN status (Amplified vs. normal) | 3.4 | (2.6–4.5) | <2.0 × 10−16 | 1.6 | (1.1–2.3) | 4.40 × 10−3 |
Univariate and multivariate analysis of overall and event-free survival assessed by Cox regression in the test set. Significant p-values are depicted in bold. HR: Hazard ratio. CI: Confidence interval. UF: unfavorable. F: favorable. INSS: international neuroblastoma staging system.