Table 4.
Summary of Kaplan-Meier estimates of OS and EFS based on the NB-hop prediction after subdividing patients of the batch-adjusted test set into sub-cohorts.
| F NB-hop | UF NB-hop | ||||||
|---|---|---|---|---|---|---|---|
| Population | Survival Probability | SEM | No. of Patients | Survival Probability | SEM | No. of Patients | p |
| Stage 1 (n = 95) | 91 | 4 | |||||
| 5-year OS | 0.98 | 0.01 | 0.5 | 0.2 | <0.0001 | ||
| 5-year EFS | 0.95 | 0.02 | 0 | 0 | <0.0001 | ||
| Stage 2 (n = 85) | 78 | 7 | |||||
| 5-year OS | 0.96 | 0.02 | 0.57 | 0.18 | <0.0001 | ||
| 5-year EFS | 0.75 | 0.05 | 0.33 | 0.19 | 0.06 | ||
| Stage 3 (n = 73) | 56 | 17 | |||||
| 5-year OS | 0.87 | 0.04 | 0.29 | 0.11 | <0.0001 | ||
| 5-year EFS | 0.65 | 0.06 | 0.23 | 0.1 | 0.008 | ||
| Stage 4 (n = 231) | 133 | 98 | |||||
| 5-year OS | 0.63 | 0.04 | 0.32 | 0.04 | <0.0001 | ||
| 5-year EFS | 0.5 | 0.04 | 0.25 | 0.04 | <0.0001 | ||
| Stage 4s (n = 66) | 56 | 10 | |||||
| 5-year OS | 0.89 | 0.04 | 0.9 | 0.09 | ns | ||
| 5-year EFS | 0.72 | 0.06 | 0.77 | 0.13 | ns | ||
| Age at diagnosis <18 months (n = 321) | 279 | 42 | |||||
| 5-year OS | 0.94 | 0.01 | 0.61 | 0.07 | <0.0001 | ||
| 5-year EFS | 0.79 | 0.02 | 0.46 | 0.07 | <0.0001 | ||
| Age at diagnosis >=18 months (n = 229) | 135 | 94 | |||||
| 5-year OS | 0.62 | 0.04 | 0.27 | 0.04 | <0.0001 | ||
| 5-year EFS | 0.51 | 0.04 | 0.2 | 0.04 | <0.0001 | ||
| MYCN single copy (n = 436) | 382 | 54 | |||||
| 5-year OS | 0.88 | 0.01 | 0.5 | 0.06 | <0.0001 | ||
| 5-year EFS | 0.72 | 0.02 | 0.32 | 0.06 | <0.0001 | ||
| MYCN amplified (n = 111) | 29 | 82 | |||||
| 5-year OS | 0.31 | 0.08 | 0.3 | 0.05 | ns | ||
| 5-year EFS | 0.33 | 0.09 | 0.25 | 0.04 | ns |
SEM indicates the standard error of mean. ns stands for not significant result. Survival curves have been compared by approximate log-rank test or exact log-rank test when approximate log-rank p value < 0.0001 or >0.0001, respectively.