Table 7.
Univariate logistic regression analysis of known covariates on the Agilent262 test set.
| Covariate | OR | 95% CI | p Value |
|---|---|---|---|
| Age at diagnosis (≥18 months vs. <18 months) | 3.1 | (1.6–5.7) | 3.03 × 10−4 |
| ALT (Yes vs. No) | 0.6 | (0.2–1.5) | 3.00 × 10−1 |
| Event Overall (Yes vs. No) | 8.4 | (3.9–18.4) | 7.77 × 10−8 |
| Event-free (Yes vs. No) | 4.3 | (2.3–7.8) | 2.12 × 10−6 |
| TERT Rearrangement (Yes vs. No) | 1.8 | (0.7–4.4) | 1.00 × 10−1 |
| INSS stage (4 vs. 1, 2, 3, 4 s) | 3.8 | (2.1–6.9) | 1.11 × 10−5 |
| MYCN status (Amplified vs. Normal) | 31.9 | (13.2–73.9) | 1.21 × 10−14 |
| P53/RAS gene mutations (Yes vs. No) | 3.7 | (1.9–7.3) | 8.18 × 10−5 |
| Spontaneous regression (Yes vs. No) | 0.1 | (0.02–0.7) | 2.00 × 10−2 |
| Telomere.Maintenance (Yes vs. No) | 16.70 | (7.3–38.2) | 2.80 × 10−11 |
Analysis was assessed by Logistic regression analysis using BayesGLM method. Covariates are sorted in alphabetic order. NB-hop prediction was used as reference class for the analysis. Significant p-values are depicted in bold. Odd ratio indicates the constant effect of hypoxia on the likelihood that one outcome will occur. OR: Odd ratio. CI: Confidence interval. UF: unfavorable. F: favorable. INSS: international neuroblastoma staging system; ALT: Alternative lengthening of telomeres.