Table 1.
Comparison of baseline characteristics and clinical presentation between patients with and without prolonged QTc on admission.
| QTc ≤ 480 (n = 562) |
QTc > 480 (n = 61) |
p-Value | Standardized Differences | |
|---|---|---|---|---|
| Women | 237 (42.2) | 30 (49.2) | 0.29 | 0.14107 |
| Age, years | 62.9 ± 16.9 | 76.6 ± 12.6 | <0.001 | −0.92172 |
| Diabetes | 88 (15.7) | 30 (49.2) | <0.001 | 0.76703 |
| Hypertension | 244 (43.4) | 46 (75.4) | <0.001 | 0.68911 |
| Dyslipidemia | 179 (31.9) | 33 (54.1) | <0.001 | 0.46121 |
| CV Risk factors | 360 (64.1) | 55 (90.2) | <0.001 | 0.65377 |
| Obesity | 97 (21.7) | 15 (28.8) | 0.239 | 0.16617 |
| Ischemic chronic disease | 36 (6.4) | 15 (24.6) | <0.001 | 0.51915 |
| Atrial fibrillation or flutter | 37 (6.6) | 15 (24.6) | <0.001 | 0.51245 |
| Heart failure | 20 (3.6) | 13 (21.3) | <0.001 | 0.55858 |
| Moderate to severe valve heart disease | 14 (2.5) | 9 (14.8) | <0.001 | 0.44769 |
| COPD | 42 (7.5) | 10 (16.4) | 0.017 | 0.27780 |
| Cancer | 64 (11.4) | 14 (23.0) | 0.010 | 0.31028 |
| CKD | 39 (6.9) | 18 (29.5) | <0.001 | 0.61132 |
| Peripheral vascular disease | 20 (3.6) | 7 (1.5) | 0.004 | 0.30370 |
| Stroke | 27 (4.8) | 8 (13.1) | 0.007 | 0.29411 |
| Systolic blood pressure, mmHg | 128.3 ± 19.0 | 130.4 ± 24.1 | 0.43 | −0.09693 |
| Diastolic blood pressure, mmHg | 77.1 ± 13.3 | 74.5 ± 16.4 | 0.23 | 0.17954 |
| Heart rate, bpm | 91.2 ± 18.0 | 88.3 ± 21.5 | 0.27 | 0.13995 |
| Respiratory rate, rpm | 24.5 ± 7.1 | 25.6 ± 7.1 | 0.37 | −0.15164 |
| Oxygen saturation, % | 95.1 ± 4.4 | 93.8 ± 6.1 | 0.13 | 0.23793 |
| Baseline FiO2, % | 25.9 ± 16.0 | 33.3 ± 25.4 | 0.033 | −0.34956 |
| PaO2/FiO2 < 300, n (%) | 180 (42.8) | 30 (60.0) | 0.020 | 0.35028 |
| Hemoglobin, g/dL | 13.6 ± 1.6 | 12.5 ± 2.0 | <0.001 | 0.59990 |
| White blood cell count, per µL | 7.04 ± 3.54 | 8.99 ± 4.76 | 0.003 | −0.46572 |
| Lymphocytes, per µL | 1.40 ± 2.2 | 1.74 ± 2.64 | 0.35 | −0.13720 |
| Platelet count | 209.0 ± 78.3 | 223.1 ± 109.0 | 0.33 | −0.14919 |
| Creatinine, mg/dL | 1.02 ± 0.56 | 1.66 ± 1.44 | 0.001 | −0.58761 |
| eGFR, mL/min/1.73 m2 | 83.0 ± 29.2 | 59.1 ± 32.0 | <0.001 | 0.77871 |
| Creatine phosphokinase, U/L | 93 (57–170) | 95 (47–290) | 0.97 | −0.18600 |
| Serum lactate, mmoL/L | 1.44 ± 0.67 | 1.76 ± 0.92 | 0.028 | −0.39636 |
| CRP, mg/dL | 9.4 ± 8.4 | 13.6 ± 11.0 | 0.005 | −0.43681 |
| Procalcitonin, ng/mL | 0.11 (0.08–0.21) | 0.22 (0.11–0.70) | <0.001 | 0.06087 |
| Lactate dehydrogenase, U/L | 309.9 ± 131.3 | 368.1 ± 159.1 | 0.003 | −0.39636 |
| D-dimer, ng/mL | 670 (430–1120) | 980 (650–1950) | <0.001 | −0.30192 |
| High sensitivity troponin T > 14 ng/L | 142 (30.7) | 42 (77.8) | <0.001 | 1.07117 |
| NT-proBNP, pg/mL | 157 (39–417) | 2065 (416–6780) | <0.001 | −0.68728 |
| Baseline QTc duration, milliseconds | 430.2 ± 23.5 | 505.4 ± 31.9 | <0.001 | −2.68874 |
| Abnormal chest radiography | 495 (88.7) | 54 (91.5) | 0.51 | 0.09446 |
Results are expressed as mean ± standard deviation, median and (interquartile range) or number and (percentage). COPD: chronic obstruction pulmonary disease, CKD: chronic kidney disease, CRP: C-reactive protein. CV: Cardiovascular. eGFR: estimated glomerular filtration rate.