. 2020 Sep 11;10(9):629. doi: 10.3390/brainsci10090629

Table 5.

Adolescents/adults with FXS in placebo-treated failed clinical trials: outcome measures improved.

Endpoint	Correlation	of Studies	Heterogeneity (I²)	Heterogeneity p-Value	Meta-Analysis Type	Mean Score Change	95%CI		Change p-Value	% Improvement
Endpoint	Correlation	of Studies	Heterogeneity (I²)	Heterogeneity p-Value	Meta-Analysis Type	Mean Score Change	Lower	Upper	Change p-Value	% Improvement
Caregiver Rated										ND
Vineland-II Comp	0.7	4	0.00	0.44	Fixed	1.74	0.08	3.39	0.040	ND
Vineland-II Comp *	0.5	4	0.00	0.44	Fixed	1.74	0.08	3.39	0.040	ND
ABC-C_FX Total	0.7	2	0.00	0.72	Fixed	−8.60	−12.45	−4.76	<0.001	ND
ABC-C_FX Total *	0.5	2	0.00	0.72	Fixed	−8.60	−12.45	−4.76	<0.001	ND
ABC-C_FX Hyper	0.7	2	0.00	0.84	Fixed	−1.37	−2.26	−0.49	0.002	ND
ABC-C_FX Hyper *	0.5	2	0.00	0.84	Fixed	−1.37	−2.26	−0.49	0.002	ND
ABC-C_FX SA	0.7	3	0.79	0.01	Random	−1.65	−2.61	−0.68	0.001	ND
ABC-C_FX SA *	0.5	3	0.79	0.01	Random	−1.65	−2.61	−0.68	0.001	ND
ABC-C_FX Stereo	0.7	2	0.00	0.69	Fixed	−1.04	−1.58	−0.50	<0.001	ND
ABC-C_FX Stereo *	0.5	2	0.00	0.69	Fixed	−1.04	−1.58	−0.50	<0.001	ND

Abbreviations: FXS, fragile X syndrome; Vineland-II Comp, Vineland Adaptive Behavior Scale-2nd edition, Composite; ABC-C_FX Hyper, Aberrant Behavior Checklist-Community Hyperactivity refactored for FXS; ABC-C_FX Stereo, Stereotypy; ABC-C_FX SA, Social Avoidance; ABC-C_FX Total, Total Score; ND, no data. * Meta-analysis conducted using a pre-post correlation of 0.0 has almost identical values.