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. 2020 Aug 25;10(9):1236. doi: 10.3390/biom10091236

Table 1.

Modifications of the oligonucleotide structure and their effects on the inhibition of the Ku70/IN complex formation.

graphic file with name biomolecules-10-01236-i001.jpg

ODN-E Sequence, 5′-3′ IC50, nM
11-OM-E GGUUUUUGUGU-EosinY 135 ± 20
11-D-E GGTTTTTGTGT-EosinY 150 ± 30
11-DX-E-1 GGTTTTTxGTxGTx-EosinY 160 ± 55
11-DX-E-2 GGTxTxTxTTGTGT-EosinY 150 ± 40
11-DS-E GsGsTsTsTsTsTsGsTsGsTs-EosinY 40 ± 10
Hex-11-D HEX-GGTTTTTGTGT 170 ± 45
Hex-11-ddR HEX-(ddR)10T No inhibition up to 3200 nM
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