Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 1;8(3):351. doi: 10.3390/vaccines8030351

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Y-5A15 immunization decreased cerebral amyloid-β (Aβ) peptide levels in the brains of APP/PS1 transgenic mice. (a) Representative microscopic images of brain sections from different groups. Sections were stained with the anti-human Aβ antibody 4G8 (Green) and thioflavin S (ThS), counterstained with DAPI (blue) to detect nuclei. The number of 4G8-positive (b) and ThS-positive plaques (c) were quantified in the hippocampus (Hip) and cortex (Ctx) by IpWin5 software. (d) ELISA analyses of insoluble human Aβ40 and Aβ42 in the brains. (e) ELISA analyses of soluble human Aβ40 and Aβ42 in the brains. Compared with AD control, * p < 0.05, ** p < 0.01, Student’s t-test, n = 6 mice per group. Scale bar is 200 μm.