Table 4.
Multivariable adjusted associations of CaScore with all-cause mortality, cardiovascular events, and cardiovascular mortality.
| Low | Medium | High | Continuous | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Hazard Ratio | Hazard Ratio | 95% CI | Hazard Ratio | 95% CI | P (Trend) Value | Hazard Ratio | 95% CI | p-Value | |
| All-cause mortality | |||||||||
| Univariate | 1.0 (Ref) | 2.12 | 1.08–4.15 | 5.22 | 2.84–9.58 | <0.0001 | 2.02 | 1.59–2.56 | <0.0001 |
| Model 1 | 1.0 (Ref) | 2.20 | 1.12–4.32 | 5.45 | 2.94–10.07 | <0.0001 | 2.02 | 1.60–2.56 | <0.0001 |
| Model 2 | 1.0 (Ref) | 1.61 | 0.80–3.25 | 3.40 | 1.69–6.85 | <0.001 | 1.72 | 1.31–2.28 | <0.001 |
| Model 3 | 1.0 (Ref) | 1.39 | 0.67–2.88 | 3.31 | 1.60–6.87 | <0.001 | 1.75 | 1.31–2.33 | <0.001 |
| Model 4 | 1.0 (Ref) | 1.28 | 0.61–2.70 | 2.84 | 1.34–6.00 | 0.002 | 1.59 | 1.19–2.14 | 0.002 |
| Model 5 | 1.0 (Ref) | 1.27 | 0.60–2.66 | 2.59 | 1.22–5.51 | 0.006 | 1.53 | 1.14–2.06 | 0.005 |
| Model 6 | 1.0 (Ref) | 1.50 | 0.64–3.51 | 3.12 | 1.34–7.26 | 0.006 | 1.72 | 1.22–2.43 | 0.002 |
| Cardiovascular mortality | |||||||||
| Univariate | 1.0 (Ref) | 3.42 | 1.07–10.91 | 7.86 | 2.63–23.47 | <0.0001 | 2.27 | 1.55–3.34 | <0.0001 |
| Model 1 | 1.0 (Ref) | 3.45 | 1.08–11.05 | 7.69 | 2.55–23.14 | <0.0001 | 2.24 | 1.53–3.29 | <0.0001 |
| Model 2 | 1.0 (Ref) | 2.40 | 0.72–8.00 | 4.66 | 1.38–15.74 | 0.009 | 1.94 | 1.24–3.04 | 0.004 |
| Model 3 | 1.0 (Ref) | 1.91 | 0.56–6.59 | 4.32 | 1.22–15.38 | 0.014 | 1.92 | 1.19–3.09 | 0.007 |
| Model 4 | 1.0 (Ref) | 1.65 | 0.47–5.74 | 4.40 | 1.19–16.24 | 0.013 | 2.03 | 1.20–3.42 | 0.008 |
| Model 5 | 1.0 (Ref) | 1.64 | 0.46–5.76 | 4.46 | 1.19–16.71 | 0.014 | 2.04 | 1.20–3.45 | 0.008 |
| Model 6 | 1.0 (Ref) | 2.30 | 0.64–8.32 | 55.67 | 1.68–8.32 | 0.004 | 2.13 | 1.32–3.43 | 0.002 |
| Cardiovascular events | |||||||||
| Univariate | 1.0 (Ref) | 2.13 | 1.19–3.84 | 2.86 | 1.62–5.08 | <0.001 | 1.56 | 1.25–1.95 | <0.0001 |
| Model 1 | 1.0 (Ref) | 2.20 | 1.22–3.98 | 2.61 | 1.46–4.64 | <0.001 | 1.60 | 1.28–1.99 | <0.0001 |
| Model 2 | 1.0 (Ref) | 1.88 | 1.00–3.53 | 2.45 | 1.25–4.81 | 0.010 | 1.48 | 1.13–1.93 | 0.004 |
| Model 3 | 1.0 (Ref) | 1.69 | 0.89–3.20 | 2.58 | 1.20–4.77 | 0.013 | 1.48 | 1.12–1.94 | 0.005 |
| Model 4 | 1.0 (Ref) | 1.48 | 0.76–2.88 | 2.13 | 1.05–4.35 | 0.034 | 1.39 | 1.04–1.85 | 0.025 |
| Model 5 | 1.0 (Ref) | 1.47 | 0.76–2.85 | 1.98 | 0.97–4.07 | 0.060 | 1.35 | 1.01–1.80 | 0.042 |
| Model 6 | 1.0 (Ref) | 1.47 | 0.76–2.87 | 2.17 | 1.08–4.37 | 0.028 | 1.45 | 1.09–1.92 | 0.010 |
Data are presented as hazard ratio and 95% confidence interval (CI) for the tertiles (low, medium, high) and the continuous (natural log transformed) CaScore outcome; p-values in bold indicate statistical significance. Model 1: adjusted for transplant center and time between computed tomography and transplantation; Model 2: adjusted for model 1 plus age at time of transplantation, and gender; Model 3: adjusted for model 2 plus BMI, total cholesterol level, diabetes mellitus, smoking status, and systolic blood pressure; Model 4: adjusted for model 3 plus type of dialysis (pre-emptive, hemodialysis, peritoneal dialysis), dialysis vintage pre-transplantation, and number of previous transplantations; Model 5: adjusted for model 4 plus Charlson Comorbidity Index; Model 6: adjusted for model 2 plus one year-post transplant variables (eGFR, calcium, phosphate, albumin, PTH).