Table 4.
Risk for development of CRAB-criteria in patient subgroups selected by a specific number of FL in the respective anatomic area.
| Anatomic Area | Spine | Spine Plus Pelvis | Whole-Body | Spine Plus Pelvis | Whole-Body |
|---|---|---|---|---|---|
| cutoff | >1 FL | >1 FL | >1 FL | >3 FL | >4 FL |
| n subgroup | 7 | 16 | 25 | 5 | 5 |
| Hazard ratio [95%-CI 1] | 1.93 [0.60, 6.22] |
2.83 [1.36, 5.87] |
2.96 [1.61, 5.46] |
4.50 [1.61, 12.58] |
4.50 [1.61, 12.58] |
| p-value | 0.264 | 0.004 | <0.001 | 0.002 | 0.002 |
| Sensitivity 2 (%) | 9 | 29 | 38 | 13 | 13 |
| FPR 3 (%) | 3 | 6 | 11 | 1 | 1 |
| 2YPR 4 in (%) [95%-CI 1] | 42.9 [0.0, 69.9] |
57.1 [23.8, 75.9] |
48.6 [24.4, 65.0] |
80.0 [0.0, 96.5] |
80.0 [0.0, 96.5] |
| median TTP 5 (months) | n.a. | 15 | 34 | 8 | 8 |
1 CI: confidence interval. 2 Sensitivity to detect patients who develop CRAB-criteria within 2 years. 3 FPR: false positive rate. 4 2YPR: 2-year progression rate (regarding development of CRAB-criteria). 5 TTP: time to progression (regarding development of CRAB-criteria). n.a.: not available: median time to progression was not reached in this subgroup.