Table 1.
List of the TMX family members. The table displays the main features of the five TMXs including their active site sequences and biological functions. a, active type-a TRX-like domain; b, inactive type-b TRX-like domain; R, reductase activity; O, oxidase activity.
| Protein | TRX-Like Domains | Active Site | Activities | Biological Functions |
|---|---|---|---|---|
| TMX1 | a | CPAC | R | Protein folding and ERAD Ca2+ flux regulation |
| TMX2 | a | SNDC | ? | Nuclear protein import Ca2+ flux regulation |
| TMX3 | abb’ | CGHC | O | ? |
| TMX4 | a | CPSC | R | Protein folding |
| TMX5 | a | CRFS | ? | ? |