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. 2020 Sep 1;12(9):2483. doi: 10.3390/cancers12092483

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Arsenic trioxide/Lenalidomide (ATO/Lena) enhanced survival and decreased ascites volume in NOD/SCID primary effusion lymphoma (PEL) mice. (a) Kaplan-Meier graphs of overall survival curves of BC-3 (left) and BCBL-1 (right) NOD/SCID mice. Mice (n = 4 per condition) were injected with 2 million BC-3 or BCBL-1 cells. ATO, Lena, or their combination were administered from day 4 until day 35 post-injection of PEL cells. (b) Ascites volume from BC-3 (left) or BCBL-1 (right). PEL mice were allowed to develop ascites for 6 weeks then were treated daily with ATO, Lena, or their combination for one week before sacrifice. (**) indicates p < 0.01; and (***) indicates p < 0.001.