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. 2020 Sep 7;9(9):2044. doi: 10.3390/cells9092044

Figure 2.

Figure 2

IL-23 proximal signaling cascade: Janus tyrosine kinases (JAKs)/signal transducer and activator of transcription (STATs) module. IL-23 receptor complex is associated with the JAK family members Jak2 and Tyk2. IL-23 binding to the IL-23R promotes JAKs activation and phosphorylation of Tyr residues (pY) in both the JAKs themselves and in the IL-23R cytoplasmic tail, creating docking sites for STAT3 monomers through Src homology 2 domains (SH2). Active Jak2/Tyk2 phosphorylate STAT3 monomers, leading to dimerization, nuclear translocation, and DNA binding to target gene promoters.