Skip to main content
. 2020 Sep 7;9(9):2044. doi: 10.3390/cells9092044

Figure 4.

Figure 4

IL-23-regulated transcription factors. IL-23 induces the expression of the transcription factor retinoic acid receptor-related orphan receptor-γt (RORγt), master regulator of Th17 cell differentiation and essential for IL-17 production and IL-23R expression. IL-23 promotes the expression of the transcription factor Blimp1, required for GM-CSF production and IL-23R expression in Th17 cells. IL-23 stimulation increases the expression of the chromatin organizer Satb1 that in turn promotes Bhlhe40 expression that are required for GM-CSF production. IL-23 promotes IκBα phosphorylation and proteasomal degradation, allowing NF-κB translocation to the nucleus and the induction of the receptor activator of NF-κB ligand (RANKL) expression, a key osteoclastogenic cytokine involved in bone destruction and arthritis pathology.