Figure 2.

Recommended clopidogrel doses when de-escalating. When de-escalating from ticagrelor or prasugrel to clopidogrel in the early phase (≤30 days after the index event), a loading dose of 600mg should be administered 24 h after the last dose of the potent P2Y₁₂ inhibitor. In the late phase (>30 days after the index event), a loading dose of 600 mg should only be administered from ticagrelor to clopidogrel, while a maintenance dose of 75 mg should be administered when de-escalating from prasugrel to clopidogrel. If de-escalating due to bleeding or bleeding concerns, a 75 mg clopidogrel dose could be considered instead of a loading dose irrespective of the phase or initial P2Y₁₂ inhibitor.