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. 2020 Aug 21;12(9):2369. doi: 10.3390/cancers12092369

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Photodynamic therapy using talaporfin sodium (TS-PDT) decreased tumor blood flow in a mouse model of HCT116 subcutaneous tumor. Mouse xenograft tumor models were established using the HCT116 colon cancer cell line. (a) Tumor blood flow was measured using a laser speckle blood flow analysis system, OMEGAZONE2. One representative experiment out of seven is shown here. (b) The blood flow ratio was calculated by dividing the flow post TS-PDT with the flow before TS-PDT. Data are presented as the means ± SE from seven independent experiments. The results for the different groups were analyzed and compared using the Bonferroni–Holm method; * p < 0.05.