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KYNUNERINE PATHWAY: indole-2,3-dioxygenase (IDO) and Tryptophan-2,3-dioxygenase (TDO) lead to Kynurenine synthesis from Tryptophan (TRP), which can be metabolized via two distinct pathways: the neuroprotective kynurenic acid (KYNA) branch via the KYN amino transferase enzyme (KAT), and the neurotoxic branch leading to the production of 3-hydroxy-L-KYN (3-HK) and quinolinic acid (QUIN).
