Figure 5.

Entosis in BxPC3 cells. Entosis without degeneration (A). One single cell is surrounded by the host cell. Membranes of both cells remain intact; the inner entotic cell seems to be localized within a large vacuole formed by the host cell (B). Double Cell-in-Cell structure. The internalizing cells are stretched and have a narrow area of the cytoplasm. Their nuclei have a crescent shape (C). Metaphase of mitosis of an inner entotic cell inside a cell that exhibits entosis-like appearance, such as the crescent nucleus and stretched cell membranes with a narrow region of cytoplasm. Confocal scan by SP5 Leica confocal microscope. Cytoplasm is stained with CFDA-SE in green and nuclei with DAPI in blue. Scale bar: 10 µm. Data by Izabela Mlynarczuk-Bialy (M.D., Ph.D.), and Agnieszka Sarnecka (M.D.), and Lukasz Bialy (M.D., Ph.D.).