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. 2020 Jun 30;8(3):348. doi: 10.3390/vaccines8030348

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Frequency and proportion of MBC responders induced by 4vHPV. (A) Frequency of HPV-16- (left panel) and HPV-18-specific (right panel) specific memory B cells (MBCs) per millions of total IgG-secreting B cells at Days 0, 365, 545 and 730 in the prospective cohort for all (solid blue line), HPV-naïve (dashed red line) and HPV-exposed (dashed green line) subjects; (B) proportion of MBC responders (defined as subjects with >455 L-16 B cell or >450 L-18 B cell per millions of total IgG-secreting B cells) to HPV-16- (left panel) and HPV-18- (right panel) in the prospective cohort at Days 365, 454 and 730 as indicated at x-axis for all (blue bar), HPV-naïve (red bar) and HPV-exposed (green bar) subjects.

Frequency and proportion of MBC responders induced by 4vHPV. (A) Frequency of HPV-16- (left panel) and HPV-18-specific (right panel) specific memory B cells (MBCs) per millions of total IgG-secreting B cells at Days 0, 365, 545 and 730 in the prospective cohort for all (solid blue line), HPV-naïve (dashed red line) and HPV-exposed (dashed green line) subjects; (B) proportion of MBC responders (defined as subjects with >455 L-16 B cell or >450 L-18 B cell per millions of total IgG-secreting B cells) to HPV-16- (left panel) and HPV-18- (right panel) in the prospective cohort at Days 365, 454 and 730 as indicated at x-axis for all (blue bar), HPV-naïve (red bar) and HPV-exposed (green bar) subjects.