. 2020 Jun 30;8(3):348. doi: 10.3390/vaccines8030348

Table 3.

Correlation between CD4+ T Cell and antibody responses for HPV-16 and HPV-18 in the prospective cohort.

Timepoint			Antibody Titer by Study Time Point
Type	Cytokine Study Time Point	Statistics	Day 67 (Dose 2 + 7 Days)	Day 187 (Dose 3 + 7 Days)	Day 365	Day 545	Day 730
HPV-16	Day 67 (Day 7 postdose 2)	Number of Subjects	44	40	39	37	34
		Correlation Statistic ¹	0.366	0.568	0.529	0.470	0.479
		p-value ²	0.0146	0.0001	0.0005	0.0033	0.0041
	Day 187 (Day 7 postdose 3)	Number of Subjects	37	37	36	34	32
		Correlation Statistic ¹	0.378	0.525	0.530	0.379	0.400
		p-value ²	0.0211	0.0008	0.0009	0.0269	0.0232
HPV-18	Day 67 (Day 7 postdose 2)	Number of Subjects	44	40	39	37	34
		Correlation Statistic ¹	0.416	0.334	0.415	0.376	0.275
		p-value ²	0.0050	0.0352	0.0087	0.0217	0.1150
	Day 187 (Day 7 postdose 3)	Number of Subjects	38	38	37	35	33
		Correlation Statistic ¹	0.400	0.383	0.311	0.287	0.210
		p-value ²	0.0128	0.0175	0.0607	0.0946	0.2395

Subjects with both values at a time point are summarized. ¹ Spearman Rank Correlation Coefficient. ² p-value is testing the null hypothesis of zero correlation.