Table 3.

Invasive diagnostic criteria for CMD.

Clinical Feature	Dysfunction	Diagnostic Criteria
Microvascular angina	Impaired coronary vasodilatation	CFR < 2.0
	Increased microvascular resistance	IMR ≥ 25 units
	Microvascular spasm	angina symptoms after intracoronary Ach Ischemic ECG changes <90% diameter reduction
Vasospastic angina	Epicardial spasm	Angina symptoms after intracoronary Ach Infusion and Ischemic ECG changes with >90% epicardial coronary constriction

Exclusion of significant obstructive CAD (FFR > 0.80). FFR: fractional flow reserve; CFR: coronary flow reserve; IMR: index of microvascular resistance; Ach: acetylcholine.