Figure 2.

Drug tracer imaging detects in vivo tumor avidity for therapeutic small molecule compounds. Axial CT (top) and PET/CT fusion (bottom) images from 57-year-old female with clear cell carcinoma of Müllerian origin, including biopsied malignant pulmonary mass (arrow). PET/CT image obtained 24 h after injection with I-124 PU-H71 radiotracer, an isotopologue of the epichaperome inhibitor therapeutic compound PU-H71. PET demonstrates marked retention of drug by tumor, after drug has cleared from blood circulation (e.g., cardiac blood pool, asterisk).