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. 2020 Aug 24;9(9):1951. doi: 10.3390/cells9091951

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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ERAP1, ERAP2/Iso1 and ERAP2/Iso3 mrna expression is increased following microbial stimulation. pbmcs isolated from 8 heteroab and 6 homob individuals were in vitro stimulated with microbial antigens (flu, CMV) inactivated viruses (i-SARS-CoV-2, HIV-AT-2) bacterial by-products (LPS) or inflammatory stimuli (IFNα, IL-1β) for ten h. mRNA expression for ERAP2/Iso3 (A), ERAP2/Iso1 (B) and ERAP1 (C) were assessed by RT-Real-Time PCR. Results are shown as the media of the relative expression units to the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and β-actin reference genes calculated by the 2^−ΔΔCt equation. (D) The microbial-dependent genetic control of ERAP2/Iso3 expression is underlined by the observation that its abundances are nearly doubled in HapB homozygotes compared to heterozygotes. Results are expressed as mean ± ES. * = p < 0.05; ** = p < 0.01.