Figure 5.

From bottom to the top, this is the whole story of current efforts to find repositionable drug candidates for emerging disease. DBs, as the foundation of drug repositioning, can be created from various computational and experimental approaches. The second way of categorizing DBs (assay-based classification) is depicted here as three in silico and three laboratory-based approaches in yellow gears to construct a DB. Afterwards, DBs can pave the way for various categorizations of systems medicine (shown in green gears) to decipher many probabilities in the case of disease mechanisms; disease stratification; therapy options; and diagnostic, prognostic, or theranostic features of biomarkers.