Table 2.
Biochemical parameters measured in the serum from 6 h fasted WT and Gpr109a−/− mice treated or not with Tb.
| WT | Gpr109a −/− | |||
|---|---|---|---|---|
| HFD (n = 12, 13) | HFD+Tb (n = 13, 14) | HFD (n = 8, 9) | HFD+Tb (n = 9) | |
| TAG (mg/dL) | 47.8 ± 11.3 | 55.1 ± 15.4 | 101.4 ± 45.1 | 64.3 ± 23.7 * |
| Cholesterol (mg/dL) | 125.3 ± 56.2 | 150.7 ± 59.8 | 177.5 ± 19.5 | 144.6 ± 42.8 |
| LDL (mg/dL) | 86.9 ± 43.0 | 105.5 ± 48.0 | 117.6 ± 12.9 | 100.2 ± 31.5 |
| HDL (mg/dL) | 28.1 ± 13.3 | 34.2 ± 13.9 | 36.1 ± 10.8 | 31.7 ± 14.5 |
| NEFA (mM) | 0.54 ± 0.12 | 0.40 ± 0.07 *** | 0.56 ± 0.10 | 0.46 ± 0.10 * |
| AST (U/mL) | 12.29 ± 2.13 | 12.71 ± 1.73 | 12.81 ± 2.10 | 11.83 ± 2.02 |
| ALT (U/mL) | 8.20 ± 1.48 | 8.21 ± 1.18 | 10.11 ± 1.94 | 10.04 ± 1.63 |
Data are presented as mean ± SD. *** p < 0.001, * p < 0.05 comparisons between HFD and HFD+Tb of the same genotype. Results analyzed using Student’s t-test.