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. 2020 Aug 25;12(9):2413. doi: 10.3390/cancers12092413

Figure 1.

Figure 1

Effects of 1,25(OH)2D3 on the phenotype of human colon and breast carcinoma cells and colon tumor organoids. (a) Phase-contrast and immunofluorescence confocal microscopy images of SW480-ADH human colon carcinoma cells treated with 100 nM 1,25(OH)2D3 or vehicle for 72 h. Scale bars, 50 μm. (b) Phase-contrast microscopy images of MDA-MB-453 human breast carcinoma cells treated with 100 nM 1,25(OH)2D3 or vehicle for 72 h. Scale bars, 50 μm. (c) Electron microscopy images of human colon tumor organoids treated with 100 nM 1,25(OH)2D3 or vehicle for 96 h. Scale bars, 2 μm. A, autophagic vacuoles; G, Golgi complexes; L, lumen; N, nucleus; RER, rough endoplasmic reticulum; arrows, desmosomes; asterisks, heterochromatin aggregates.