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. 2020 Aug 26;12(9):2425. doi: 10.3390/cancers12092425

Table 6.

The impact of solid dispersion and microemulsions on the solubility and bioavailability of carotenoids.

Purpose of the Study Study Details Results Reference
Solubility of β-carotene Solid dispersion prepared by hot-melt technology with polyvinylpyrrolidone and sucrose fatty acid esters Rats High solubility [226]
Hot-melt technology (solid dispersions technology)—the weight ratio of β-carotene:polyvinylpyrrolidone:sucrose fatty acid ester to 10%:70%:20% Improved water solubility of β-carotene [227]
Bioaccessibility of β-carotene, lycopene Pitanga (E. uniflora) and buriti (M. flexuosa) microemulsions: direct processing (high-speed homogenization at 15,000 rpm and ultrasound with 20 kHz probe at 40% amplitude) of the whole pulp together with surfactant (Tween 80 or Whey Protein Isolate at 2%) and corn oil (5%) Dynamic gastrointestinal system (simulation of human digestion) Surfactant and oil: protection of carotenoids in fruits and microemulsions [228]
Final recovery of total carotenoids, higher for microemulsions than for whole pulps
High losses of total carotenoids in buriti and β-carotene and lycopene in pitanga during jejunum and ileum phases