Table 2.

Genetic distribution of our Alzheimer’s Disease Italian cohort for APOE, MTHFR, and COMT genes polymorphisms.

APOE Haplotypes (rs429358 and rs7412)			MTHFR (rs1801133: C677T)			MTHFR (rs1801131: A1298C)			COMT (rs4680: V158M)
HWE	χ2 = 0.91	p = 0.92	HWE	χ2 = 1.70	p = 0.19	HWE	χ2 = 0.53	p = 0.47	HWE	χ2 = 1.22	p = 0.27
Alleles	N	freq	Alleles	N	freq	Alleles	N	freq	Alleles	N	freq
ɛ2	20	0.03	T	314	0.43	A	499	0.69	A	330	0.46
ɛ3	510	0.70	C	410	0.57	C	225	0.31	G	394	0.54
ɛ4	194	0.27
total	724	1.00	total	724	1.00	total	724	1.00	total	724	1.00
Genotypes	N	freq	Genotypes	N	freq	Genotypes	N	freq	Genotypes	N	freq
ɛ2 ɛ3	16	0.04	TT	62	0.17	AA	169	0.47	AA	70	0.19
ɛ2 ɛ4	4	0.01	TC	190	0.52	AC	161	0.44	AG	190	0.52
ɛ3 ɛ3	178	0.49	CC	110	0.30	CC	32	0.09	GG	102	0.28
ɛ3 ɛ4	138	0.38
ɛ4 ɛ4	26	0.07
total	362	1.00	total	362	1.00	total	362	1.00	total	362	1.00
ɛ2 carriers	20	0.06	T carriers	252	0.70	A carriers	330	0.91	A carriers	260	0.72
ɛ3 carriers	332	0.92	C carriers	300	0.83	C carriers	193	0.53	G carriers	292	0.81
ɛ4 carriers	168	0.46

Note: APOE: Apolipoprotein E; MTHFR: Methylenetetrahydrofolate Reductase; COMT: Catechol-O-Methyltransferase; HWE: Hardy-Weinberg equilibrium.