Table 5.
Clinical distributions of behavioral endophenotypes in our Italian Alzheimer’s Disease cohort.
| Mean of N Subjects ± SD £ (% Mean of N Subjects ± SD) $ |
||||
|---|---|---|---|---|
| Endophenotypes (Components; “Severity*Frequencies” Range) |
Mean ± SD § | Free | Low | High |
| Psychosis (Delusions, Hallucination, Agitation, Aberrant motor behavior, Night-time behavior disturbances; 0–60) | 18.5 ± 13.3 | 148 ± 32 (48.0 ± 10.5) | 47 ± 6 (15.4 ± 2.1) | 113 ± 37 (36.6 ± 11.8) |
| Hyperactivity (Agitation, Irritability, Appetite and eating disturbances; 0–36) | 11.4 ± 9.2 | 145 ± 68 (46.9 ± 22.0) | 42 ± 13 (13.7 ± 4.1) | 122 ± 56 (39.4 ± 18.0) |
| Mood (Depression, Anxiety, Apathy; 0–36) | 8.1 ± 9.4 | 188 ± 11 (61.2 ± 3.8) | 42 ± 12 (13.6 ± 3.7) | 77 ± 9 (25.0 ± 3.0) |
| Frontal (Euphoria, Disinhibition; 0–24) | 1.0 ± 2.7 | 276 ± 33 (89.9 ± 10.6) | 17 ± 16 (5.5 ± 5.1) | 14 ± 17 (4.6 ± 5.5) |
Note: § Mean ± standard deviation (SD) of the scores relative to “severity*frequencies” of the endophenotype components. Free: NPI = 0 for all the individual components involved in the endophenotype; Low: Sum of the “severity*frequencies” score (NPI 1–4) for all the individual components involved in the endophenotype; High: Sum of the “severity*frequencies” score (NPI 6–12) for all the individual components involved in the endophenotype. £ Mean number of subjects N ± SD present in each group (Free, Low, and High) compared to individual endophenotypes. $ Percentage (%) of the mean of the number of subjects (N ± SD) present in each group (Free, Low, and High) compared to individual endophenotypes.