Table 6.
Genetic correlates related to single BPSD symptoms in our Italian Alzheimer’s Disease cohort according to different values of “severity*frequencies” (exhaustive CHAID data mining algorithm).
| Gene | Free + Low & | High & | ||
|---|---|---|---|---|
| N (Freq.) | N (Freq.) | |||
| Agitation | APOE | χ2 = 7.435, padjusted = 0.006 OR = 1.87; 95% CI: 1.19–2.95 |
||
| Ɛ4-carriers | 58 (0.39) | 86 (0.54) | ||
| Ɛ4-non-carriers | 91 (0.61) | 72(0.46) | ||
| total | 149 (1.00) | 158 (1.00) | ||
| Aberrant motor behavior | APOE | χ2 = 7.553, padjusted = 0.006 OR = 1.91; 95% CI: 1.20–3.04 |
||
| 4-carriers | 76 (0.41) | 68 (0.57) | ||
| Ɛ4-non-carriers | 111 (0.59) | 52 (0.43) | ||
| total | 187 (1.00) | 120 (1.00) | ||
| Delusions | MTHFR | χ2 = 4.363, padjusted = 0.037 OR = 1.75; 95% CI: 1.04–2.94 |
||
| CC | 59 (0.27) | 35 (0.39) | ||
| Genotypes_C677T | 159 (0.73) | 54 (0.61) | ||
| T-carriers_C677T | 218 (1.00) | 89 (1.00) | ||
| Appetite/eating abnormalities | APOE | χ2 = 5.922, padjusted = 0.015 OR = 2.06; 95% CI: 1.14–3.71 |
||
| Ɛ4-carriers | 109 (0.44) | 35 (0.60) | ||
| Ɛ4-non-carriers | 141 (0.56) | 22 (0.40) | ||
| total | 250 (1.00) | 57 (1.00) |
Note: & Free + Low: “severity*frequencies” scores (NPI 0–4) for all individual symptoms; High: “severity*frequencies” scores (NPI 6–12) for all the individual symptoms. OR: Odd ratio.