Cells targeted |
All the organism |
Inflammatory cells |
Mechanism of action |
Genomic modulation |
Membrane receptor and intracellular inflammatory pathways |
Start of action |
~4 to 6 h |
~15 min |
Saturation dose of the immunosuppressive – anti-inflammatory effects |
~100% at 30 to 40 mg/day of prednisone-equivalent |
Unknown |
Minimum effective dose |
2.5 to 5 mg/day of prednisone-equivalent |
Over 100 mg of prednisone-equivalent |
Maximum effective doses that minimize adverse effects |
30 to 40 mg/day of prednisone-equivalent (for trans-repression) |
500/day mg of methylprednisolone |
Damage accrual with cumulative doses |
Proven |
Not proven |
Glucocorticoids acting by this way |
All |
Mainly methylprednisolone and dexamethasone |