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HSP70 chaperone machinery. HOP and CHIP compete for HSP70’s C-terminus during protein folding and degradation, while HIP and Bag-1 compete for the ATPase domain. Depending on the site of HIP or Bag-1 binding, HSP70 may lead to protein folding (HIP/HOP pathway; (A) or to protein degradation through the proteasome (CHIP/Bag-1 pathway; (B). Ub = ubiquitin.
