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Rituximab (RTX) inhibits NF-κB signalling in pSS SGEC. The pSS SGs epithelial cells (SGEC) were found to express low levels of Raf-1 kinase inhibitor protein (RKIP). In a co-culture system with pSS B-lymphocytes, the FcγR-mediated interaction of RTX/CD20 induces the upregulation of RKIP expression, decreasing NF-κB activity, and, consequently, inhibiting the pro-inflammatory genes transcription.
