Table 3. Change in Distance High-Contrast Visual Acuity From Enrollment to 6 Months by Baseline Subgroupsa.
| Variable | Enrollment | 6-Mo visit | |||||
|---|---|---|---|---|---|---|---|
| Eyes, No. | Mean (95% CI) | Eyes, No. | Mean (95% CI) | ||||
| HCVA logMAR score | Group difference for logMAR scoreb | HCVA logMAR score | Change from enrollment in logMARc,d | Group difference for change in logMARc | |||
| Overall | 54 | 0.95 (0.75 to 1.16) | NA | 45 | 0.12 (−0.01 to 0.26) | 0.76 (0.54 to 0.99) | NA |
| Age, y | −0.06 (−0.12 to −0.00)e | −0.005 (−0.045 to 0.034)e | |||||
| 3-6 | 14 | 1.2 (0.8 to 1.6) | NA | 13 | 0.1 (−0.2 to 0.4) | 1.13 (0.70 to 1.55) | NA |
| 7-9 | 9 | 1.1 (0.6 to 1.6) | 7 | −0.1 (−0.4 to 0.3) | 1.01 (0.47 to 1.55) | ||
| 10-12 | 20 | 0.8 (0.5 to 1.2) | 16 | 0.2 (0.0 to 0.5) | 0.44 (0.08 to 0.80) | ||
| ≥13 | 11 | 0.8 (0.3 to 1.2) | 9 | 0.1 (−0.2 to 0.3) | 0.68 (0.23 to 1.13) | ||
| Diagnosis | |||||||
| Isolated optic neuritis | 27 | 0.6 (0.3 to 0.8) | 1 [Reference] | 22 | −0.0 (−0.2 to 0.2) | 0.44 (0.15 to 0.72) | 1 [Reference] |
| Neurological association | 27 | 1.3 (1.1 to 1.6) | 0.68 (0.34 to 1.01) | 23 | 0.2 (0.1 to 0.4) | 1.06 (0.79 to 1.33) | −0.205 (−0.497 to 0.087) |
| Laterality | |||||||
| Bilateral | 26 | 1.1 (0.8 to 1.4) | 0.08 (−0.35 to 0.50) | 20 | 0.2 (−0.0 to 0.5) | 0.82 (0.45 to 1.20) | −0.189 (−0.523 to 0.145) |
| Unilateral | 28 | 0.9 (0.6 to 1.1) | 1 [Reference] | 25 | 0.1 (−0.1 to 0.2) | 0.73 (0.44 to 1.01) | 1 [Reference] |
| MRI lesions | |||||||
| Lesions present | 27 | 1.3 (1.1 to 1.6) | 0.70 (0.36 to 1.04) | 21 | 0.2 (0.0 to 0.4) | 1.07 (0.78 to 1.36) | −0.087 (−0.379 to 0.204) |
| None | 27 | 0.6 (0.3 to 0.8) | 1 [Reference] | 24 | 0.1 (−0.1 to 0.2) | 0.48 (0.20 to 0.76) | 1 [Reference] |
| Puberty statusf | |||||||
| Prepuberty | 12 | 0.8 (0.4 to 1.3) | −0.12 (−0.63 to 0.39) | 10 | −0.0 (−0.3 to 0.3) | 0.81 (0.28 to 1.35) | 0.159 (−0.203 to 0.520) |
| Puberty/postpuberty | 31 | 1.0 (0.7 to 1.2) | 1 [Reference] | 27 | 0.2 (−0.0 to 0.3) | 0.75 (0.46 to 1.05) | 1 [Reference] |
| Unknown/not reported | 11 | NA | NA | 8 | NA | NA | NA |
| White/non-Hispanic | |||||||
| No | 25 | 1.3 (1.1 to 1.6) | 0.61 (0.26 to 0.95) | 20 | 0.2 (0.0 to 0.4) | 1.06 (0.75 to 1.36) | −0.096 (−0.387 to 0.196) |
| Yes | 27 | 0.7 (0.4 to 0.9) | 1 [Reference] | 23 | 0.1 (−0.1 to 0.2) | 0.55 (0.27 to 0.84) | 1 [Reference] |
| Unknown/not reported | 2 | NA | NA | 2 | NA | NA | NA |
Abbreviations: MRI, magnetic resonance imaging; NA, not available.
CIs for mean distance visual acuity score (enrollment and 6-month visit) and change in visual acuity from enrollment to 6 months are adjusted for intereye correlation for participants who contributed both eyes.
With the exception of puberty status, group differences in mean distance visual acuity (logMAR) at enrollment were adjusted for age at enrollment.
Group differences in mean change (logMAR) in distance visual acuity from enrollment to the 6-month visit were adjusted for baseline covariates (continuous factors) of visual acuity and age (except for puberty status).
Distance visual acuity at 6 months was tested using a different method from enrollment for 7 eyes (16%).
Age at baseline was included as a continuous factor in the linear models; therefore, the estimate represents the difference in change in logMAR visual acuity for each additional year of age.
Group comparisons were not adjusted for baseline age due to collinearity between puberty and age at enrollment.