Table 3.
Neisseria meningitidis B cases, incidences and impact for age groups, vaccinated or not, in Tuscany and Veneto during pre and post-vaccination eras.
| PRE—4CMenB | POST—4CMenB | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age Groups | Number of Cases | Incidence * (Cases/100.000) | Number of Cases | Vaccinated Cases | Crude Incidence * (Cases/100.000) | ASR | Crude Incidence on Vaccinated Cases | ASR on Vaccinated Cases | IRR | IRR on Vaccinated Cases | Overall Impact (%) | Total Impact (%) |
| (A) TUSCANY | ||||||||||||
| 0–1 | 14 | 5.537 (5.44–5.62) | 2 | 1 | 1.452 (1.39–1.51) | 0.232 | 0.726 | 0.116 | 0.260 | 0.131 | 74% | 87% |
| 1–2 | 5 | 1.749 (1.70–1.80) | 1 | 0.887 (0.68–1.02) | 0.160 | 0.507 | 49% | |||||
| 2–3 | 2 | 0.631 (0.60–0.66) | 1 | 1.160 (1.00–1.50) | 0.232 | 1.838 | ||||||
| 3–4 | 7 | 2.007 (1.96–2.05) | 0 | |||||||||
| 4–5 | 3 | 0.789 (0.76–0.82) | 0 | |||||||||
| TOTAL | 31 | 1.956 | 4 | 1 | 0.941 | 0.624 | 0.726 | 0.116 | 0.320 | 0.060 | 68% | 94% |
| (B) VENETO | ||||||||||||
| 0–1 | 17 | 4.647 (4.33–4.97) | 3 | 1.956 (1.52–2.40) | 0.409 | 0.421 | 58% | |||||
| 1–2 | 6 | 1.447 (1.41–1.48) | 3 | 2 | 2.552 (2.46–2.64) | 0.605 | 0.851 | 0.200 | 1.764 | 0.590 | 41% | |
| 2–3 | 5 | 1.082 (1.05–1.11) | 1 | 1.253 (1.18–1.33) | 0.330 | 1.158 | ||||||
| 3–4 | 6 | 1.181 (1.15–1.21) | 0 | |||||||||
| TOTAL | 34 | 1.942 | 7 | 2 | 1.789 | 1.344 | 0.851 | 0.200 | 0.692 | 0.103 | 31% | 90% |
Abbreviations: 4CMenB = multicomponent meningococcal serogroup B vaccine; ASR = Age Standardized Incidence; Rate IRR = Incidence Rate Ratio. * in brackets 95% CL.