Table 5.
Prognostic value of nucleosomes on disease-free survival in primary breast cancer (nucleosomes dichotomized below vs. above mean).
| Variable | HR | 95% CI Low | 95% CI High | p-Value |
|---|---|---|---|---|
| All | 0.46 | 0.19 | 1.12 | 0.05 |
| T-stage | ||||
| T1 | 0.29 | 0.08 | 1.02 | 0.04 |
| >T1 | 0.56 | 0.14 | 2.19 | 0.33 |
| Histology | ||||
| IDC | 0.35 | 0.14 | 0.91 | 0.01 |
| other | 0 | 0 | 0 | 0.33 |
| Grade | ||||
| low and intermediate | 0.31 | 0.07 | 1.34 | 0.09 |
| high grade | 0.48 | 0.15 | 1.55 | 0.15 |
| Lymph nodes | ||||
| N0 | 0.86 | 0.15 | 4.92 | 0.86 |
| N+ | 0.36 | 0.13 | 1.04 | 0.03 |
| Lymphovascular invasion | ||||
| absent | 0.46 | 0.14 | 1.53 | 0.15 |
| present | 0.54 | 0.15 | 1.97 | 0.31 |
| Hormone receptor status (cut-off 1%) | ||||
| negative for both | 0.36 | 0.04 | 3.33 | 0.21 |
| positive for either | 0.41 | 0.15 | 1.15 | 0.06 |
| HER2 status | ||||
| negative | 0.55 | 0.19 | 1.6 | 0.23 |
| positive | 0.3 | 0.06 | 1.55 | 0.09 |
| P53 status | ||||
| negative | 0.48 | 0.16 | 1.44 | 0.13 |
| positive | 0.39 | 0.08 | 1.86 | 0.20 |
| BCL-2 | ||||
| negative | 0.25 | 0.05 | 1.17 | 0.02 |
| positive | 0.59 | 0.19 | 1.85 | 0.33 |
| Ki67 status (cut-off 14%) | ||||
| <14% | 0.73 | 0.11 | 4.71 | 0.72 |
| >14% | 0.35 | 0.12 | 1 | 0.02 |
| CTC EP | ||||
| negative | 0.31 | 0.12 | 0.83 | 0.01 |
| positive | 0 | 0 | 0 | 0.18 |
| CTC EMT | ||||
| negative | 0.68 | 0.23 | 2.03 | 0.46 |
| positive | 0.17 | 0.03 | 0.9 | 0.01 |
| CTC ANY | ||||
| negative | 0.45 | 0.13 | 1.52 | 0.14 |
| positive | 0.5 | 0.14 | 1.87 | 0.27 |
p-Values < 0.05 are written in Bold.