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. 2020 Aug 28;10(9):1251. doi: 10.3390/biom10091251

Figure 4.

Figure 4

E100 and DOZ restored the abnormal anxiety and hyperactivity observed in BTBR mice in OFT. BTBR mice (red) demonstrated enhanced impulsive attitude and cognition deficits in as well as hyperactivity that was significant compared to Ctrl mice (gray). All mice were administered subchronically for 21 days with E100 (at a dose of 5, 10 or 15 mg/kg, i.p in green) or DOZ (1 mg/kg, i.p. in blue) and showed attenuation in the increased (A) time spent in the central zone as well as (C) the elevated total distance traveled, but failed to modulate the (B) time spent in the periphery in BTBR mice in the OFT. Effects of subchronic (21 days) systemic co-injection of RAM (10 mg/kg, i.p.) on the E100 (5 mg)-provided amelioration of time spent in the center and decreased (C) distance traveled of BTBR mice were evaluated in OFT. Data are expressed as the mean ±SEM (n = 4). * p < 0.05 compared to saline treated Ctrl mice. # p < 0.05 compared to saline treated BTBR mice. $ p < 0.05 compared to E100 (5 mg)-treated BTBR mice.