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. 2020 Aug 31;12(9):2467. doi: 10.3390/cancers12092467

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Abiraterone efficiently suppresses DSB repair in fresh PCa tissues after ex vivo irradiation. (a) Representative immunofluorescence micrographs for γH2AX (red) and 53BP1 (green) foci after the indicated treatments in freshly collected tumor tissue from PCa patient P5. (b) Abiraterone-mediated enhancement ratio (AbiER) on γH2AX (left panel) and 53BP1 (right panel) foci of 22 punch biopsies from 15 PCa patients. (c,d) Correlation between (C) AbiER or (D) BicaER on γH2AX and 53BBP1 foci. Threshold in grey was calculated as the mean standard error for each DSB marker in all samples.